منابع مشابه
Neurohormones regulate T cell function
In this communication we show that T cell locomotion is affected by direct interaction with neurohormones. Opioid peptides, including beta-END, MET-ENK, LEU-ENK, and related enkephalin analogues enhanced migration of human peripheral blood T lymphocytes. Activity was dependent on the peptide NH2-terminal sequence, stimulated by enkephalin analogues with specificity for classical delta or mu typ...
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Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function by Thomas F. O’Brien Department of Immunology Duke University Date:_______________________ Approved: ___________________________ Xiao-Ping Zhong, Supervisor ___________________________ Garnett Kelsoe, Chair ___________________________ Yuan Zhuang ___________________________ You-Wen He ___________________________ Jeffrey Rathmell...
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The regulation of CD4 T-cell numbers during an immune response should take account of the amount of antigen (Ag), the initial frequency of Ag-specific T cells, the mix of naive versus experienced cells, and (ideally) the diversity of the repertoire. Here we describe a novel mechanism of T-cell regulation that potentially deals with all of these parameters. We found that CD4 T cells establish a ...
متن کاملMicroRNAs regulate dendritic cell differentiation and function.
MicroRNAs (miRNAs) are an important class of cellular regulators that modulate gene expression and thereby influence cell fate and function. In the immune system, miRNAs act at checkpoints during hematopoietic development and cell subset differentiation, they modulate effector cell function, and they are implicated in the maintenance of homeostasis. Dendritic cells (DCs), the professional APCs ...
متن کاملMicroRNAs regulate Dendritic Cell Development and Function
microRNAs have emerged as a novel layer of regulation of cellular development and function, including cells of the immune system. microRNA expression profiles and function of several microRNAs have been elucidated in granulocyte macrophage colony-stimulating factor derived dendritic cells (GM-CSF DC). In this studywedetermined themicroRNAexpressionprofile fromplasmacytoidDC (pDC) and convention...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1990
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.171.5.1625